There's no way to pronounce this word, which describes an alignment of three heavenly bodies, without sounding like you've had too much to drink. But it's a cool and impressive word to keep in mind for Scrabble.
To begin with, you'll score at least 21 points for "syzygy." Of course, you'll need to use a blank, because there are only two "y" tiles in Scrabble. But you can amp up your score if you bring the word into alignment with one of the corners. Hit the double letter square with the "z" and end on a triple word square, and you'll have a total of 93. A great move when you're short of vowels.