Dubliners by James Joyce
It took 22 rejections before a publisher took a chance on a young James Joyce in 1914. They didn't take too big of a chance -- only 1,250 copies of Dubliners were initially published. Joyce's popularity didn't hit right away; out of the 379 copies that sold in the first year, Joyce himself purchased 120 of them. Joyce would go on to be regarded as one of the most influential writers of the 20th century. Dubliners, a collection of short stories, is among the most popular of Joyce's titles, which include A Portrait of the Artist as a Young Man, Finnegans Wake, and Ulysses.