5 Best Anime Duos: Iconic BFFs, Frenemies, Lovers, and Pets

Two brothers, one goal: to restore their bodies after a failed alchemy experiment.

Edward and Alphonse from "Fullmetal Alchemist" are a dynamic duo defined by an unbreakable bond, forged in tragedy and tested through countless battles.

Their journey explores life, death, ethics, and brotherhood, with a relationship that literally transcends body and soul. Fans connect with their fierce loyalty and combined strength, making them one of anime's most emotionally resonant pairs.

What starts as a fight to the death turns into a lifelong rivalry rooted in mutual respect. Goku and Vegeta are two of the most iconic characters in anime history.

Their personalities clash constantly—Goku's carefree spirit meets Vegeta's pride and intensity—but when evil threatens the world, they set aside their differences and unite.

Whether battling Majin Buu or fusing into Vegito, these Saiyans show how rivalry can fuel growth and strength. Their evolving relationship remains a major draw for "Dragon Ball" fans.

Naruto and Sasuke define "complex relationship." From childhood rivals to bitter enemies to reluctant allies, their story is filled with pain, betrayal, and redemption. Yet their connection always stays central to the narrative of "Naruto."

Their battles are legendary, their emotions intense, and their bond feels earned through years of conflict and growth. It's a relationship that shows how friendship can endure even when paths diverge.

Ash and Pikachu are inseparable. Since the pilot episode of "Pokémon," their partnership has charmed millions around the world. They might not have the deepest plot arcs, but their loyalty and teamwork resonate across generations.

Ash doesn't just command Pikachu; he learns from him. Their friendship shows the heart of "Pokémon": forming bonds with others, fighting alongside your team, and never giving up.

Half-demon warrior meets time-traveling schoolgirl. Inuyasha and Kagome blend action, romance, and spiritual growth in one of anime's most memorable duos. Their relationship grows from bickering allies to deeply connected partners in both love and battle.

Fighting monsters, recovering sacred shards, or just navigating their feelings, Inuyasha and Kagome prove that even clashing personalities can form a powerful, heartfelt team.

We created this article in conjunction with AI technology, then made sure it was fact-checked and edited by a HowStuffWorks editor.