Hanging Up (2000)
Ephron and her sister Delia teamed up for the first Ephron film of the 21st century, about a trio of sisters who bond over the death of their father. Stereotypical "hysterical-female" breakdowns and makeups occur, played out by A-list actors Meg Ryan, Diane Keaton (who also directed), and Lisa Kudrow. The film was panned by critics and only brought in $36 million -- about half as much as it cost to make. The movie was based on a book written by Delia Ephron, but it simply didn't translate to the screen as well as the sisters would've liked.