- The Dodgers win the 1965 National League flag by 2 games over Giants.
- The Twins take the franchise's first American League flag since 1933.
- LA wins the 1965 World Series in seven games after dropping first two contests in Minnesota.
- Sandy Koufax wins two CG shutouts in the 1965 World Series, including a crucial seventh game 2-0 over Jim Kaat.
Walter Alston, manager
of the LA Dodgers, wins
his fourth World Series.
- LA manager Walter Alston wins a National League record fourth World Series.
- Sandy Koufax fans 29 Twins in three games of the 1965 World Series.
- Ron Fairly of LA leads all 1965 World Series hitters with .379 BA, 11 hits, and six RBI.
- Mudcat Grant wins two games for the Twins in the 1965 World Series.
- Willie Mays is named 1965 National League MVP.
- Minnesota's Zoilo Versalles is chosen as the 1965 American League MVP over teammate Tony Oliva.
- Willy Mays leads the majors in homers (52), total bases (360), SA (.645), and OBP (.399).
- For the second time, Sandy Koufax is the unanimous choice for Cy Young, as he Ks 382 to set a new major league record.
- Koufax tops the majors with 26 wins, 336 innings, 27 CGs, and 2.04 ERA.
- The majors adopt an annual free agent (rookie) draft.
- Minnesota wins 102 games after winning 79 the year before.
- Jim Maloney of the Reds pitches a no-hitter for ten innings over the Mets on June 14, but loses in 14 innings.
- Pittsburgh's Bob Veale tops the majors with 250 Ks.
- Jim Maloney has to go ten hitless innings to win a no-hitter, 1-0 over Chicago on August 19.
- The National League wins the All-Star Game 6-5 in Minnesota, and for the first time takes the lead in All-Star victories.
- At 60, Satchel Paige becomes the oldest man to play in a major league game when he hurls three scoreless innings for KC vs. Boston on Sept. 25.
- Sandy Koufax pitches a perfect game and his major league record fourth no-hitter in four years, beating Chicago 1-0 on Sept. 9.
- The first indoor stadium, the Astrodome, opens on April 9 -- Houston vs. Yankees in an exhibition game.
- The Mets lose 112 games for a four-year major league record of 452 losses.
- Bert Campaneris plays all nine positions for the A's on Sept. 8.
- Spike Eckert replaces Ford Frick as baseball's commissioner.
- Jerry Kindall leaves the majors with a .213 career BA, the lowest in the 20th Century by an infielder or outfielder.
- Ted Abernathy's 31 saves for Cubs set a new major league record.
- Dave Morehead of Boston no-hits Cleveland on September 16.
- Tony Oliva again leads the American League in batting (.321), and also leads in hits (185) and runs produced (189).
- Carl Yastrzemski tops the American League in OBP (.398) and SA (.536), and ties for the lead in doubles (45).
- Boston's Tony Conigliaro leads the American League with 32 homers, and at 20 is the youngest ever to win a league homer crown.
- Zolio Versalles tops the American League in runs (126) and total bases (308), and ties for the lead in doubles (45) and triples (12).
- Cleveland's Sam McDowell leads the American League in ERA (2.18) and sets a new American League southpaw record for Ks (325).
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