"Like sands through the hourglass . . ." faithful viewers have been watching Days of Our Lives since it debuted on November 8, 1965. Days takes place in the fictional midwestern town of Salem, with most scenes shot at University Hospital or the Brady Pub. Today, Salem is home to the respectable Horton and Brady families, as well as the evil DiMeras. Since the show debuted more than 40 years ago, matriarch Alice Horton has been portrayed by award-winning actor Frances Reid. In the 1980s, the "Salem Stalker" and "Salem Slasher" brought romantic adventure to the forefront, while in the 1990s, Dr. Marlena Evans-Black (Deidre Hall) was possessed by the devil.